Restoring hearing in mice
نویسندگان
چکیده
منابع مشابه
Preventing Hearing Loss and Restoring Hearing: A New Outlook
People with hearing loss represent one of the largest disability groups worldwide, and the prevalence of hearing loss is predicted to rise with an ageing population. Substantial progress has been made towards understanding some of the biological processes involved in the development of hearing impairment as well as therapeutic ways to prevent or mitigate the hearing loss. For example, we now ha...
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With today's technology and the demonstrated success of cochlear implantation, along with expanded candidacy criteria, the opportunity to provide optimal hearing to both ears for individuals with severe-to-profound hearing loss is greater than ever. This article reviews the advantages of binaural hearing and the disadvantages of hearing with only one ear or hearing with two ears with significan...
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Hearing loss is the most frequent sensory disorder in humans. Auditory hair cells (HCs) are postmitotic at late-embryonic differentiation and postnatal stages, and their damage is the major cause of hearing loss. There is no measurable HC regeneration in the mammalian cochlea, and the maintenance of cell function is crucial for preservation of hearing. Here we generated mice deficient in autoph...
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Five conditioned and five unconditioned response procedures for assessing hearing in mice are reviewed. The five conditioned response procedures are conditioned suppression/avoidance, go/no-go, eyeblink conditioning, avoidance conditioning, approaching the source of a sound, and GSR conditioning. Of these, the conditioned suppression/avoidance procedure is the most effective as it has the short...
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Xeroderma pigmentosum (XP) is a rare recessive heredity disease caused by DNA repair impairment characterized by photosensitivity and neurologic symptoms in half of the cases. There are eight subtypes of XP: XP-A-XP-G and XP variant. Among eight subtypes, XP complementation group A (XP-A) display the lowest DNA repair ability and the severest cutaneous and neurologic symptoms. While its pathoge...
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ژورنال
عنوان ژورنال: Lab Animal
سال: 2020
ISSN: 0093-7355,1548-4475
DOI: 10.1038/s41684-020-0605-2